Effects of acute high intensity intermittent exercise on gut permeability following ibuprofen or placebo ingestion

Nonsteroidal anti-inflammatory drugs (NASIDs) are widely available over the counter agents used in the acute and chronic treatment of soft-tissue injuries as well as for analgesic purposes. Due to NSAIDs analgesic, anti-inflammatory, and antipyretic effects, they have become one of the most commonly used drug groups by recreational and high level athletes to ameliorate a plethora of musculoskeletal pathologies including post exercise muscle soreness. In particular prevalence data- on the use of NSAIDs indicates team sports participants express high consumption rates of both officially prescribed and unofficially consumed NSAIDs. The -high prevalence rates of NSAID consumption for prophylactic purposes are often accompanied by limited awareness of the side effects of their use and more appropriately overuse particularly on a chronic basis.